Treatment of the arthropathy of familial hypercholesterolaemia.

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Treatment of the arthropathy of familial hypercholesterolaemia.

A 29-year-old woman suffering from the arthropathy of familial hypercholesterolaemia was treated with a fat-modified low-cholesterol diet and colestipol. Symptomatic improvement occurred in association with a moderate reduction in the plasma cholesterol concentration. The pathogenesis of the musculoskeletal features of this disease is reviewed, and the implications of this patient's therapeutic...

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Diagnosis and treatment of familial hypercholesterolaemia.

Familial hypercholesterolaemia (FH) is an autosomal dominant genetic disorder, associated with elevated levels of low-density lipoprotein-cholesterol (LDL-C), which can lead to premature cardiovascular disease. Early diagnosis of FH is important to prevent morbidity and mortality. Familial hypercholesterolaemia is usually diagnosed using clinical characteristics, such as family history, and cho...

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Use of cholestyramine in treatment of children with familial hypercholesterolaemia.

West, R. J., and Lloyd, J. K. (1973). Archives of Disease in Childhood, 48, 370. Use of cholestyramine in treatment of children with familial hypercholesterolaemia. 19 children with heterozygous familial hypercholesterolaemia have been treated with cholestyramine administered twice daily in a total dosage of 8 to 24 g/day (0 3 to 1 * 1 g/kg body weight per day). Serum cholesterol concentration ...

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Genetic Architecture of Familial Hypercholesterolaemia

PURPOSE OF REVIEW Familial hypercholesterolaemia (FH) is an inherited disorder of low-density lipoprotein cholesterol (LDL-C) which is characterised by a raised cholesterol level from birth and a high risk of premature coronary heart disease. In this paper, we review the genetic basis of FH and its impact on the clinical presentation. RECENT FINDINGS Mutations in any of three genes (LDLR, APO...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1983

ISSN: 0003-4967

DOI: 10.1136/ard.42.2.206